Present at
the meeting were AMSP staff of Drs. Marc Schuckit, Susan
Tapert, and Marianne Guschwan, as well as Marcy Gregg.
First-Year Scholars included Drs. Pirzada Sattar
(Creighton University), Alisa Busch (Harvard University),
Randy Brown (University of Wisconsin), and Carlos
Hernandez-Avila (University of Connecticut).
Second-Year Scholars included Drs. Sarah Book (Medical
University of South Carolina), Andrea DiMartini (University of
Pittsburgh Medical School), and Marian Fireman (Oregon Health
& Sciences University). Guests at the New
York meeting included Drs. Nina McGowan (New York University),
Eric Gunderson (Columbia University), Karen Drexler (Emory
University and an AMSP graduate), and Chris Welsh (University
of Maryland and an AMSP graduate).
I.
SESSION I.
The group
met together in the lobby of the Park Lane Hotel in the late
afternoon on Wednesday, March 30th.
Introductions were made, guests introduced, and we
proceeded to the evening dinner and discussion.
The evening’s activities were held at Paoli Restaurant
on East 84th Street Near Lexington Avenue.
II.
SESSION II: Thursday, March 31st.
The group
assembled at approximately 7:40 a.m. over breakfast, and the
meeting was officially called to order at 8:00 a.m.
The
meeting began with a review of the lecture entitled: “How to
Give a Lecture” as originally presented by Marc Schuckit.
The scholars were asked to think about whether this
lecture helped prepare them for the AMSP process, and to offer
suggestions about how to improve the presentation.
Among the issues raised were the suggestion that
scholars be warned that slides cannot be used instead of an
outline (or else too much information is given on the slide),
the fact that the development of lectures requires help from
additional faculty at the person’s institution, and some
specific items regarding some of the slides themselves.
Andrea
DiMartini next presented a new lecture entitled: “How to Give
a Research Lecture.” This was built
upon the original How to Give a Lecture material, and is best
delivered with the two lectures in tandem.
The lecture was felt to be very useful, and will be added to
the Web site.
The
first Junior Scholar lecture on “Benzodiazepines and Similar
Drugs” was next offered by Randy Brown.
This was an excellent presentation that will not require
much work to be placed into a form appropriate for the Web
site. This material demonstrated an
impressive evolution of Randy’s ability to organize the
material, incorporate a large number of references, and to
place together a very effective lecture format.
Over lunch,
the group discussed issues of career development.
Most of the conversation centered on ways
to balance home and work requirements.
This is an especially challenging process for women with
children, and many useful suggestions were offered.
The agenda
on the first day ended with a 30-minute version of the
lecture entitled: “Hepatitis C” as modified by the Senior
Scholar, Marian Fireman. Marian
demonstrated how relatively easily a 45-minute lecture can be
decreased to 30 minutes. In this case,
most of the changes involved decreasing the level of detail
offered regarding most of the slides. The
lecture worked well and was delivered with great skill.
The meeting
adjourned at 2:20 p.m. following a lively discussion of steps
that can be taken to modify lectures for specific situations.
III.
SESSION III, Friday, April 1st.
Our group
assembled for breakfast after 7:30 a.m., and began the
official session at 8:00 a.m.
The first
order of business was the presentation of a lecture
entitled: “A Comparison of Alcohol and Drug Dependence with
Other Chronic Medical Disorders” by Alisa Busch.
The material came across very effectively and was
delivered very well. The slides worked
well, and this excellent presentation might have been improved
even a bit more with the incorporation of a few more clinical
vignettes.
Next,
Marianne Guschwan gave a clinically-oriented talk regarding:
“Adult ADHD.” This was a fine
demonstration of an alternative approach to developing
lectures. Here, a clinician can utilize a
limited number of review papers, as well as some additional
references to pull together the basic crux of a topic.
This is a useful approach in some clinical settings,
but might prove challenging in an attempt to convince
skeptical members of an audience that there are solid data to
support the area being discussed. Marianne
offered the group an opportunity to discuss pros and cons of
the various approaches, and is looking forward to developing a
more data-oriented version of the lecture for potential
incorporation on the AMSP Web site. This
was a very lively and tremendously useful discussion.
The
Senior Scholar, Sarah Book, next presented a full 40-minute
version of her paper entitled: “Alcoholism and Social Anxiety
Disorder.” This was a fine
demonstration of the ability of a lecturer to focus the
attention of the audience, and the presentation went very
well, despite the temporary distraction caused by some noise
from construction on the street. Many of
the comments dealt with the effectiveness of this lecture and
the wonderful delivery style.
Next,
Randy Brown, a Junior Scholar, offered his report regarding
his recent activities at the University of Wisconsin.
Randy has delivered two new lectures on alcohol and
opioid withdrawal assessment and management to students in the
UW Nurse Practitioners Program specializing in acute/hospital
care; he helped develop a reading list, handouts, and a short
quiz for 2nd-year medical students for a
pharmacology course small-group session on the
pharmacotherapeutic management of heroin dependence; and he
developed a new lecture for an undergraduate sociology course
on the significance of alcohol and drug use in individuals
involved in the criminal justice system.
Dr. Brown continues to give two lectures a year to family
practice residents on the assessment of substance use
disorders (primarily opioid dependence) in patients with
chronic non-cancer pain. Randy developed a
package of instruments that was favorably reviewed as
patient-care and teaching tools by family practice residents,
and consists of an instructional video, patient-care flow
sheets, and a pain management agreement for use in monitoring
patients with chronic non-cancer pain for the signs and
symptoms of opioid dependence that will soon be used in
UW-affiliated clinics throughout the state of Wisconsin.
In his
roles as Co-Director of the UW Hospitals and Clinics AODA
Consult Service and Director of the 4th-year
medical student elective in substance use disorders, Dr. Brown
has instituted a program of formal hospital rounds with the
students on the rotation in which the students are given
instruction in the assessment of substance use disorders and
substance withdrawal. Students perform the initial assessment
on inpatients needing an AODA consult; the students then
discuss the cases with Dr. Brown, who works with the students
to formulate a management plan.
Dr. Brown
delivered a formal presentation to policy-makers and law
enforcement officials regarding the effectiveness and
potential areas for improvement in the Dane County Drug Court
Treatment Program, which provides an alternative to
incarceration and traditional adjudication for individuals
with drug-related charges and substance use disorders.
He was elected Vice-President and Membership Chair of
the Wisconsin Society of Addiction Medicine, is a member of
the Resident Education Committee to assess curricular needs in
the UW Family Practice Residency Program, and is working to
expand resident education regarding substance use disorders.
Dr. Brown
will be sitting for his preliminary examination in the
doctoral program in Population Health Sciences at UW Madison
in Spring-Summer 2005. He has been first
or second author on 5 peer-reviewed publications in the last
12 months. A sixth is currently under review.
In addition, he submitted his first application for
NIH-R01 funding as Principal Investigator in February 2005,
for a randomized clinical trial of gabapentin as adjunctive
treatment for cocaine dependence. Randy is
collaborating with a representative of the World Health
Organization, Dr. Nathanael Wright, to present at the American
Society of Addiction Medicine’s Annual Medical Scientific
Conference in April 2005. They will conduct a workshop in
which they summarize the evidence and the recently released
WHO position statement regarding drug use in homeless
populations. Dr. Brown will present
findings from his research, “Provider attitudes in caring for
patients with chronic non-cancer pain: The impact of pain
management agreements,” at the Annual Conference of the North
American Primary Care Research Group in October 2005.
Finally, Randy has been invited to speak at the annual
meeting of general practitioners for the National Treatment
Agency in the United Kingdom in Spring 2006. This is a meeting
of providers with interest in substance use disorders
treatment in primary care.
Subsequently, Junior Scholar Alisa Busch brought us up to date
on her challenges and developments at Harvard.
Dr. Busch faces a number of challenges that she is actively
addressing. Her university is in the
process of revising its medical school curriculum, and she has
been discussing this with the psychiatrist involved in the
restructuring process. She hopes to be
able to use this relationship to expand the amount of
information being offered on alcohol and drugs, coordinate the
lecture material, and work to be certain that the information
being delivered is optimal. At the same
time, she hopes to work with the every-other-Friday
medical-student get-together (students self-identified as
being interested in psychiatry) by offering them information
on alcohol and drugs.
The group offered several suggestions of additional activities
that Dr. Busch might consider. These
include working more directly with Doctors Ought to Care
(DOC), finding other student special interest groups who might
be interested (e.g, primary care), using the AMSP Web site’s
posted elective developed by Susan Tapert, and meeting with
faculty in charge of the current psychiatry course/neurology
course/pharmacology lecture series to determine whether she
might help add a lecture of two to these ongoing series.
Additionally, Dr. Busch is speaking with her clinical
supervisor who heads the Addiction Treatment Program at
McClean Hospital to discuss ways she may assist in the medical
students’/residents’ education during their clinical
clerkships/rotations in substance use disorders.
The
group then discussed career development issues over a working
lunch. Topics included how to ask for
promotion to the next level in an academic setting; the
importance of knowing the guidelines under which an individual
is being judged; how to handle workloads that might not be
fairly distributed among colleagues; and time management.
The last
official action of the day was the presentation of a
lecture entitled: “Alcohol Withdrawal” as presented by the
Junior Scholar, Carlos Hernandez-Avila.
Carlos’ material demonstrated a logical progression from a
review of key physiological data to lay the groundwork for a
clinically-oriented lecture to the discussion of the clinical
material. He was able to simplify rather
complex ideas into a lecture that was both educational and
clinically useful. The style of
presentation was quite effective.
The session
ended at approximately 2:15 p.m. as the group discussed the
lecture and the plans for the following day of work.
Everyone was reminded of a working dinner that evening.
IV.
DINNER SESSION: Friday, April 1st.
The group
met in the hotel lobby and walked together to our dinner
meeting at Remi, a restaurant at 6th Avenue and
West 53rd Street. This was a
wonderful opportunity to informally discuss presentations and
future plans. This also offered the chance
for members to begin to network together regarding future
activities.
V.
SESSION V. Saturday, April 2nd.
Following a
working breakfast, our session began at 8:00 a.m.
Senior
Scholar, Andrea DiMartini presented a 20-minute version of her
AMSP lecture entitled: “Clinical Assessment of Alcohol Use.”
Once again, presented with great skill, this lecture
demonstrated Andrea’s ability to refocus a lecture to another
audience (in this instance, Emergency Room physicians) and to
decrease the amount of time for the presentation.
As with all lectures at this meeting, this was highly
effective.
Senior
Scholar, Joseph Sakai, next presented an update of his
activities at the University of Colorado.
First, Joe’s proposal to create a substance abuse
Thread at his medical school was formally rejected by the
Curriculum Committee, but this effort had some fortunate
consequences. Because of these efforts,
Dr. Sakai has been more widely recognized as someone
interested in this topic, and he has been approached to
lecture in a fourth-year medical student clinical pharmacology
course, to be on the advisory committee for a proposal to
teach about behavior change to medical students, and to
be a faculty teacher at a local psychotherapy conference
focusing on motivational interviewing.
Joseph was also recently approached by the new psychiatry
residency training director to begin discussing how to
incorporate more teaching about substance use disorders into
their program. He has continued to teach
in Dr. Tom Crowley’s PG-III core substance use disorders
course, has continued participating in Dr. Crowley’s
fourth-year medical student elective on substance use
disorders, and recently completed delivering his six-lecture
series to psychiatry interns on substance use disorders.
Reviews of Dr. Sakai’s teaching endeavors have been
consistently very favorable. In addition,
Joe’s standardized patient, used to test medical students’
ability to screen for alcohol use disorders in a general
medical setting, will be included in the fourth-year medical
student clinical skills exam this summer, and a modified
version may again be included in assessing psychiatric
residents this fall.
In terms of
other academic pursuits, last fall Joe began a NIDA-funded
K award for which he has hired and trained a research
assistant, and has begun collecting data.
He participated in his first NIMH grant review in March 2005 (NIMH
Special Emphasis Panel for Developing an Advanced Center for
Interventions and services Research – ZMH1-ERB-P 04).
Dr. Sakai will present posters at the College on
Problems of Drug Dependence and the Research Society on
Alcoholism meeting in June. He also had
two manuscripts and two book chapters published in 2004, has
one manuscript in press, and has two in review.
Another manuscript about to be submitted directly
resulted from his work with AMSP. In 2003
and 2004, Dr. Sakai worked closely with his Vice Chair of
Education (through AMSP), Dr. Mike Weissberg, and reflecting
his continued interest in education, Dr. Weissberg invited him
to co-author a manuscript that focuses on risk-taking
attitudes and behaviors among medical students, and
students’ perceptions of how much these factors might
influence clinical decision-making.
Sarah
Book, Senior Scholar, was asked to take a few minutes to
reorganize her 45-minute lecture into a 20-minute presentation
for high school seniors. Sarah did a
wonderful job, once again showing that when one focuses on the
four basic points to be presented, and remembers to aim the
lecture toward the audience (rather than the presenter) almost
any lecture can be modified fairly quickly to address a new
and different group. This was an excellent
job and a fine demonstration of some of the most important
basic material we are trying to teach in AMSP.
Carlos
Hernandez-Avila then delivered his report on developments at
Connecticut. During the three months
prior to our meeting Carlos delivered his one-hour bimonthly
lecture to third-year medical students on Alcohol Withdrawal
and Detoxification during their rotation in the inpatient
psychiatric service. This lecture has been
well received by the students, and these efforts helped
develop the PowerPoint presentation on Alcohol Withdrawal for
the AMSP Web site. He also gave the
one-hour bimonthly case conference on Alcohol and Drug Use at
the inpatient psychiatric service, which increased the number
of hours of exposure to alcohol and substance abuse topics for
the third-year medical students and general psychiatry
residents. Next, Carlos gave the one-hour
lecture on Opioid Dependence to first-year psychiatry
residents, largely based on the AMSP presentation developed by
Joe Sakai; he gave a 45-minute lecture at the School of Public
Health to MPH students on Pharmacotherapy and Public Health;
and he delivered four one-hour lectures to social workers,
counselors and nurses from the State of CT department of
Mental Health and Addiction Services on Alcohol and Opioid
Dependence, Alcohol Withdrawal, and Genetics of Addictive
Disorders.
Sarah
Book next brought us up to date on her activities at the
Medical University of South Carolina.
As a direct result of her participation in AMSP, she is a
co-investigator of the Alcohol Research Center’s ‘Educational
Core’ renewal grant application, which is a systematic
revamping of alcoholism education at the University, including
medical students, residents, and physicians both on the
faculty and throughout the state. Dr.
Book’s role as co-investigator will be to direct the medical
student and resident component of education.
She continues her involvement the medical student and
resident selection processes, where she can influence and
encourage applicants with an interest in alcoholism to be
recruited to her university. Dr Book mentors medical students,
residents and addiction fellows and in this role has used the
helpful information she has learned in AMSP about how to be a
quality mentor.
Sarah has
refined her lecture on the Comorbidity of Social Anxiety and
Alcohol Use, and has given this lecture in several different
settings, including using the lecture to inform
representatives of industry about the importance of developing
treatments of alcoholism.
Also, Dr.
Book will complete her Masters in Clinical Research in May
2005 and is preparing an R-21 grant application to NIAAA
entitled “Topiramate vs Placebo for Alcoholism with
Co-Occurring Social Anxiety Disorder.” In
addition, she has had two first author papers accepted for
publication in scientific journals. One
paper, entitled “Novel Anticonvulsants in the Treatment of
Alcoholism,” is in press in the journal Expert Opinion.
The other one, entitled “Treating Alcoholics With a
Co-Occurring Anxiety Disorder: A Markov Model to Predict Long
Term Costs,” will be in an upcoming issue of the Journal of
Dual Diagnosis.
Finally, at
the upcoming meeting of Research Society of Alcoholism, in
Santa Barbara, California, Dr. Book will present a poster
entitled “Gender Differences in Alcohol Expectancies for
Social Situations” and will participate in a scientific
symposium by presenting her paper entitled “Treating
Alcoholics With a Co-Occurring Anxiety Disorder: A Markov
Model to Predict Long Term Costs.”
Joseph
Sakai, Senior Scholar, next delivered a 20-minute,
14-slide-based variation of his lecture on “Opioid Replacement
Therapy,” but now aimed at counselors in drug treatment
programs. The presentation was very
effective, and Joe was able to adapt the material to a totally
different audience than the one for which the material had
originally been developed.
Susan
Tapert, one of the two Associate Directors of AMSP, next
demonstrated a new lecture for our group on: “Substances and
the Brain.” In addition to her
excellent delivery style, this lecture also shared important
information highly relevant to medical students.
This will be added to our Web site.
An
update of recent developments at Creighton University was next
presented by the Junior Scholar, Pirzada Sattar.
Pirzada reported that his activities in AMSP have
facilitated his ability to increase the amount of required
education on alcohol and drugs given to medical students.
This included a doubling (from one to two hours) of the
lecture time allotted to substance use disorders for Year 1
medical students, with a similar increase for those in Year 2.
In addition, he has been given time to cover important
information regarding the application to substance use
disorders for special populations (e.g., the homeless, youth,
women, etc.). Dr. Sattar is currently
working to try to increase the amount of medical education for
medical students in Year 3 (currently he only has the
opportunity to lecture to one-third of the class), as well as
the potential for developing clinical electives for Year 4
students. Regarding psychiatry residents,
Dr. Sattar offers 12 hours of lectures to those in Year 1 and
Year 2, as well as five hours of lectures to those in Years 3
and 4. He is pleased to report that he has
had two recent publications, one dealing with training in
substance use disorders, and the other in the use of
antipsychotic medications in these conditions, and he is
planning to submit an R21 application.
Andrea
DiMartini next reviewed her accomplishments at Pittsburgh.
These included a number of activities regarding
curriculum development. First, regarding
first-year medical students, she joined the First-Year Medical
School Curriculum Committee. She joined
the first-year medical school Curriculum Committee for the
advanced physical diagnosis course and is attempting to
increase the amount of exposure of first-year medical students
to drug and alcohol issues. Four hours of didactics have been
added, as well as a half-day clinical experience at either an
inpatient or outpatient addiction treatment program, and
students will now attend a 12-step meeting.
For the didactics she plans to use her “Clinical
Assessment of Alcohol Use and Disorders” lecture and Dr.
Busch’s lecture on “Alcohol and Drug Dependence: Comparison to
Other Chronic Medical Disorders,” and hopes to develop an
interactive video interview demonstrating motivational
interviewing techniques. These didactics
will be coordinated with small group sessions the next day for
students to practice interviewing techniques with patients
with alcohol/drug disorders. This will
comprise another half day. In total, she
will have added 1½ days of drug and alcohol teaching to the
first-year medical student curriculum. All
of the drug and alcohol teaching throughout the medical
student psychiatry curriculum will be evaluated with the
intent of weaving a consistent theme throughout the four
years, with each year building on the prior year’s teaching.
This
semester Andrea designed and gave a lecture to the hepatology
fellows on alcohol use disorders and liver disease using parts
of Dr. Marian Fireman’s AMSP lecture on HCV and liver disease.
She is also giving her lecture on “How to Give a
Lecture” to graduating psychiatry residents, all of who must
give a Grand Rounds lecture to graduate.
This has now become a standard part of the psychiatry
residency curriculum. In addition, she
presents Dr. Tapert’s “PowerPoint” lecture.
The series will be expanded to include other issues of
professional development, using other AMSP lectures such as
Dr. Drexler’s “Managing References” and Drs. Tapert’s/Villier’s
“Organizing a Paper.” Beginning this year,
graduating residents also need to complete a senior project
and Andrea is working with residency training to help
residents develop their projects. Andrea
also offered the graduating residents an opportunity to work
with her on her alcohol relapse research.
Dr. DiMartini will also mentor a psychiatry resident on
alcohol research.
Currently,
Andrea is working with UPMC Website developers to create
educational materials for patients for her medical center Web
site. She hopes to have a resident design
educational material as part of their senior project.
She is also co-authoring a review article on alcohol
and drug-related issues for hepatologists, and will speak at
the APA and the Academy of Psychosomatic Medicine meetings on
psychiatry and transplantation - a third of this lecture is on
alcohol and drug issues.
Regarding
research, she presented a paper entitled “Alcohol and Tobacco
Use after Liver Transplantation for Alcoholic Liver Disease”
at the annual meeting of the American Association for the
Study of Liver Diseases, in Boston, MA on November 2, 2004,
and she will present her data on relapse after liver
transplantation for alcoholic liver disease as a poster at the
RSA meeting this June. Over the past year
as an AMSP scholar she has authored/co-authored five articles
on alcohol/substance use issues and one book chapter in which
alcohol and substance use issues were a third of the chapter.
One article was co-authored with another AMSP scholar,
Dr. Marian Fireman, regarding a review of alcohol and
substance use in transplant populations.
Marian Fireman then presented her update from the Oregon
Health & Sciences University. She
continues as the clerkship director for psychiatry.
In that role she has doubled the number of substance
use disorder lectures in the didactics for the clerkship (from
one hour to two hours) by adding a lecture she gives on
“Emergencies related to Substance Use Disorders.”
Dr. Fireman also teaches a weekly interviewing seminar
with the medical students and has a medical student one-half
day per week for an elective in the Geriatric Substance Use
Disorders Clinic. She assisted in the
development of a half-day curriculum on substance use
disorders for the third-year medical student class, which was
well received and delivered a lecture as part of that
curriculum on “Medical Complications of Substance Use
Disorders.” She has incorporated
objectives into the goals of the clerkship related to
substance use disorders. She continues as
a member of the Medical Student Education Committee and the
Clinical Services Subcommittee of the School of Medicine
Curriculum Committee. Dr. Fireman is
co-investigator on an NIH grant for enhancing Behavioral and
Social Sciences into the medical school curriculum – if this
grant is received there are proposals within the grant to
enhance teaching of substance use disorders across the entire
4-year curriculum. Marian will present a
poster on AMSP at the Association for Directors of Medical
Student Education in Psychiatry meeting in Monterey,
California in June 2005.
Dr. Fireman
has joined the Department of Psychiatry Residency Training
Committee and has initiated discussions within that committee
to enhance the three-year resident rotation in addictions and
to increase the time devoted to the addiction psychiatry
seminar given to the second and third-year residents.
She will coordinate and lecture in this seminar, which
begins in the fall of 2005. She also
presents a lecture in the neurosciences seminar on the
“Neurobiology of Withdrawal Syndromes.”
Marian interviews residency applicants and continues to
supervise residents in the outpatient clinic, the geriatric
substance use disorders clinic, the hepatitis C clinic and the
transplant clinics. The OHSU Addiction
Psychiatry Fellowship had a site visit in July 2005 and
received a positive report. The fellowship
has a new director and Marian will become more involved in the
fellowship in the future. Marian also
presented a lecture at the National VA Advanced Liver Disease
Training Program in September 2004 on Substance Use Disorders
and Liver Transplant. She will present a
similar lecture at the National VA Liver/Kidney Transplant
Conference in April 2005.
Dr. Fireman was recently
appointed to the School of Medicine Continuing Medical
Education Committee. She also serves on
three committees for the Academy of Psychosomatic Medicine:
the Fellowship and Awards Committee, the C/L Residency
Training Committee, and is Co-chairman of the Women’s Network
Committee. She is on two committees for
the Oregon Psychiatric Association (the Program Committee and
the Member’s Assistance/Board of Medical Examiners Committee),
and she is the representative from the Oregon Psychiatric
Association to the Oregon Board of Medical Examiners.
Additionally, she has had three manuscripts published
in the past year: one on med psych drug interactions —
immunosuppressants; one on transplants and substance use with
Dr. DiMartini as the lead author; and one on trimorbidity
(hepatitis C, psychiatric and substance use disorders.
Susan Tapert and Marcy Gregg then brought us up to date on
AMSP Web-site statistics. There has
been a steady increase in the number of visits, hits, and so
on throughout the year. For example, in
the first 28 days of March, 2005, there were 8138 visits,
including almost 17,000 hits, for a total number of pages
viewed of nearly 7,300. Over the months,
the most commonly viewed lectures included Substance Use Among
Athletes, the Diagnosis and Treatment Lecture, Medical
Problems Associated with Substance Use Disorders, Personality
Disorders, Substance-Related Pharmacology, and Spirituality.
Almost 400 of the hits in March 2005 came from
individuals directly seeking out our Web site.
Visits included individuals from North America, many
countries in Europe, Asia (including India, North Korea,
China, Hong Kong, the Philippines, and so on), Oceana
(including Australia, New Zealand, Guam, and Fiji), as well as
South America and Africa.
The meeting ended with a discussion of a variety of topics.
This included the selection of our next meeting date
to begin on Wednesday, September 14th and end
on Saturday, September 17th; the selection of
Monday, June 20th at 11:45 a.m. (San Diego time)
for our one-hour conference call; as well as
plans for a get together at the Research Society on
Alcoholism.
The meeting adjourned at noon on Saturday, April 2nd.
Marc A. Schuckit, M.D.